PoliticsNew drug for severe form of MS generates glimmer of hope — and tempered expectations MRI brain scan from a patient with multiple sclerosis. Dr. W. Crum/Tim Beddow/Science Source Related: There is finally some progress in the hunt for a treatment for the most difficult form of multiple sclerosis — the form that has stubbornly resisted every attempt to find a therapy.The catch, experts say, is that people with this form of the disease should keep their expectations low, because even the new drug that’s now in the last stages of development doesn’t appear to have a big clinical impact.The reason that the new drug is generating so much interest, though, is that it’s the first time a therapy for primary progressive MS has had any impact at all.advertisement ‘Fearful for the future’: Father, daughter fight different forms of MS The FDA has approved 13 drugs for treating relapsing-remitting MS, but none have been shown to work for people with primary progressive disease. The new “breakthrough” drug, called ocrelizumab, is one of six that are in various stages of development for this recalcitrant form, one that affects 10 to 15 percent of the estimated 400,000 Americans living with MS.On Friday, the company behind ocrelizumab, the Roche subsidiary Genentech, will release new Phase 3 trial data at a conference of the Americas Committee for Treatment and Research in Multiple Sclerosis, which is being held in New Orleans.Genentech has already published a first round of the results, which showed some impact on a wide range of measures for people with primary progressive MS. The new data will include more detail on how ocrelizumab affected subgroups of patients, as well as new information on how it worked in people with relapsing-remitting MS, to show whether it can also work on the more common variety of the disease.These new results will demonstrate that the drug “appears to have efficacy across the patient population” of people with primary progressive MS, including people who had active inflammation and those who didn’t, according to Dr. Peter Chin, principal medical director for neuroscience at Genentech. It will also show a “significant reduction” in the major markers of the disease for people with relapsing-remitting MS, he said.Even before those data are released, the fact that the FDA has given the coveted “breakthrough” designation to the drug has given new hope to people who have been waiting for a treatment for years.“When I found out about this this morning, it was like every cell in my body smiled,” said Gigi Ranno, an outreach coordinator for the Massachusetts Department of Conservation and Recreation, who has primary progressive MS.“I’ve had MS for over 25 years. It’s the first time that I have heard that there’s a drug that’s this close to being submitted to the FDA for approval for my kind of MS,” she said in an interview Thursday.Gigi Ranno uses a wheelchair, even for sailing, owing to her primary progressive MS. John Tlumacki/The Boston GlobeThe FDA announcement has also generated excitement among advocates like Tim Coetzee, the chief advocacy, services, and research officer at the National Multiple Sclerosis Society. “We’ve had so many failures with treatments for people with primary progressive MS that this really represents a source of hope,” he said.Experts do warn, however, that even if the drug is approved after the fast-track review, people with primary progressive MS shouldn’t expect spectacular results.“It is truly a landmark, and really provides hope to people who are living with primary progressive MS. That being said, the results are on the modest side,” said Dr. Tanuja Chitnis, a neurologist at the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital in Boston, who was not involved in the drug trials. And it’s the first MS drug to ever receive a “breakthrough” designation from the Food and Drug Administration, which puts the experimental medicine on a fast track to get through the review process as quickly as possible. The agency granted the designation earlier this week. By David Nather Feb. 19, 2016 Reprints Ocrelizumab works by targeting a certain kind of immune cell that can contribute to the damage to the nervous system, including the nerve cells and the protective covering around nerve fibers. It is taken by intravenous infusion twice a year.In the clinical trial data released last fall, which covered 732 people with primary progressive MS, people who took the drug had a 24 percent reduction in the progression of disability after 12 weeks compared to those who received a placebo. Study participants on the experimental medicine also experienced slower declines in walking ability and brain volume than people in the control group.These differences, while undramatic, were statistically significant, which is the main threshold the FDA will be looking for when it decides whether to approve the medication. “It’s a positive result when you’ve had 20 years of failure,” said Coetzee.Based on the study results, Dr. Dennis Bourdette, executive director of the Oregon Health and Science University’s Multiple Sclerosis Center, said it was “very appropriate” for the FDA to grant breakthrough status to the drug and that he was “hopeful that it will be approved for the treatment of primary progressive MS.”But Bourdette, who was not involved in the Genentech-funded trials, also noted that the patients in the study were younger than average for people with primary progressive MS, which usually begins about 10 years later than relapsing-remitting MS. Younger patients could be more responsive to treatment, and “it will be uncertain how effective ocrelizumab will be for older and more disabled patients,” he said.For Michael Bunting, 66, it’s more of a sign of distant hope than something that could give him immediate relief.Bunting, who talked to STAT last year about his battles with progressive MS, has a different variation of the disease: secondary progressive MS. That’s a kind that often begins with relapsing-remitting MS and then turns into a steady deterioration. So even if the new drug is approved, it’s not something that would necessarily help him because it’s not yet been evaluated for people with his form of the disease.Still, Bunting sees it as a big step for all MS patients, and one that could lead to more research that could eventually find a drug that would help him.“If this thing helps just in the primary progressive, that’s great, because it will help us in the long run [to] finally find something that will help the secondary,” Bunting said.“I just hope they don’t wait too long.” A progress report: Fighting the deadliest diseases, one step at a time Related: Tags FDAmultiple sclerosisneurologypharmaceuticalspolicy Primary progressive MS is a relatively rare form of the neurological disease in which a person doesn’t have severe attacks, the way people do with the more common, relapsing-remitting kind. Instead, they suffer a slow, steady physical deterioration with no hope of recovery.advertisement
FacebookTwitterWhatsAppEmail This year we celebrate our independence in the midst of an election campaign. It ought to be a model election because it was the right to vote and the struggles to secure that right that eventually led to our independence in 1962.Sadly, the election campaign has been marred by incidents of violence and a few persons have already lost their lives with three weeks left to go. It is a betrayal of the struggle that was waged and the sacrifices that were made to secure our independence.In the tumultuous events of 1938 which led to the setting up of the Moyne Commission, the granting of universal adult suffrage, the various stages of internal self-government and, eventually, independence in 1962, some people died violently. But they died for a cause. Their death was the sacrifice that they made so that we could become an independent nation governing ourselves and taking charge of our own destiny.But what are people dying for today? Why are they being killed? So that one party can be victorious over the other? That is not what those patriots who fought and gave their lives for us had intended. For, as Ernie Smith so poignantly declared in song, “as we fight one another for the power and the glory Jah kingdom goes to waste”.It is not too late, for we have three weeks to go, for us to redeem the legacy left to us by those who fought for our independence. It is not too late for those of us who offer leadership to demonstrate that leadership by recognizing that the fight for independence is over. We won that fight./245 years ago! The fight must now be to transform that independence into prosperity, to make Jamaica a land where our people live a good life, a life of peace, happiness and justice. And, in that fight, we must fight together – not each other for neither side can do it alone, none of us can make it unless all of us make it.No one can claim that in these 45 years of independence we have achieved as much as we should have achieved. There are too many other countries that have left us behind, too many people for whom independence means nothing because the condition of their lives is no better than it was without independence. And, therefore, what this election ought to be about is not a fight for the power and the glory but about the path we must take to achieve the goals of independence that have for so long eluded us.I want to see a Jamaica that is not just independent but also strong, prosperous and peaceful. I want to see a Jamaica where we respect the rights of others in the same way that our rights are respected by others, where all our people are able to enjoy a decent standard of living, where every child is able to go to a good school and every working-age adult to a decent job, where everyone might not be rich but no one has to be poor. That is my dream; that is my vision. That is what independence is all about. And that is what this election should be about.I extend a special welcome home to all Jamaicans who are visiting family and friends for the holidays.May you all have a blessed, peaceful and happy Independence! RelatedINDEPENDENCE 2007 MESSAGE FROM OPPOSITION LEADER BRUCE GOLDING, MP INDEPENDENCE 2007 MESSAGE FROM OPPOSITION LEADER BRUCE GOLDING, MP UncategorizedAugust 3, 2007 Advertisements RelatedINDEPENDENCE 2007 MESSAGE FROM OPPOSITION LEADER BRUCE GOLDING, MP RelatedINDEPENDENCE 2007 MESSAGE FROM OPPOSITION LEADER BRUCE GOLDING, MP
RelatedGov’t Needs to Build 100 Schools to Achieve Secondary Education Target FacebookTwitterWhatsAppEmail The Government will need to undertake a major programme of construction in order to remove the shift system, reduce overcrowding at the secondary level and provide education up to Grade 11.Minister of Education, Hon. Andrew Holness, making his Sectoral presentation in the House of Representatives on July 21, said that Government will have to build, refurbish and replace at least 100 schools to achieve its target.The National Education Trust, which will be launched in December of this year, will assist the Government’s efforts in attaining the goal. “We have secured funding from the United States Agency for International Development (USAID) and the World Bank, to establish the National Education Trust (NET),” Minister Holness informed.The NET will be the focal point for interfacing with the Diaspora on issues of education and national development; provide a credible institutional framework for accountability and efficient use of donated funds; and plan and execute a programme of school construction and maintenance.According to the Education Minister, “the plan is to build out the new schools required at the secondary level to ease the bottleneck at GSAT (Grade Six Achievement Test) and take all secondary schools off shifts. It is estimated that we would need to construct 30 new high schools and expand 10 schools to remove the shift system at the secondary level.“We would also need to construct an additional 30 high schools to reduce overcrowding and accommodate students of secondary age who are not presently in the school system,” Mr. Holness informed.In so doing, he said, the 43 all-age and junior high schools, presently operating on double shift, will have to be reverted to single shift primary schools, utilising the junior secondary space for additional primary age students.The remaining 28 double-shift primary schools would be taken off shift strategically, by a process of rationalisation and consolidation, replacement, expansion and new construction, the Minister added.It is estimated to cost about US$6.5 million to build a school to accommodate 1,200 students, using traditional building methods, and equipped to the standards set by the Ministry.The exploding demand for places in the 1970s resulted in the implementation of the shift system as a short-term solution. Three decades later, there are 154,341 students attending 116 schools that remain on shift.“The shift system has a major negative impact on the quality of education. If we are serious about quality, then we must provide universal secondary education, we must remove the shift system, and we must reduce overcrowding. Building more schools and improving the ones we have will increase access but it will also increase quality,” Mr. Holness said. RelatedGov’t Needs to Build 100 Schools to Achieve Secondary Education Target Gov’t Needs to Build 100 Schools to Achieve Secondary Education Target EducationJuly 22, 2009 RelatedGov’t Needs to Build 100 Schools to Achieve Secondary Education Target Advertisements
Advertisements FacebookTwitterWhatsAppEmail The Portmore Fishing Village Complex in St. Catherine has been completed and vendors and fishers are to be fully relocated to the site within a month.The facility, located on the Jamworld property at Dyke Road, was officially opened yesterday (October 30) by Minister of Transport and Works, Hon. Michael Henry.It will accommodate fisherfolk, who previously plied their trade along the Portmore Causeway, but had to be relocated to facilitate construction of the Portmore leg of Highway 2000.The project was funded and implemented by the National Road Operating and Constructing Company (NROCC), which represents Government’s interests in the Highway 2000 project, while M and M Jamaica Limited, an engineering and project management company, carried out construction works.During the brief opening ceremony, Mr. Henry informed that close to $300 million was spent on the project, which comprised beach improvement works, including the dredging of a boat channel for fishing boats; and construction of 110 units for fishermen and 34 vending stalls. The complex also has secure storage cubicles for the fishermen, bathroom facilities inclusive of septic tank and tile field for drainage, and areas to accommodate restaurants.The Minister informed that in order to ensure that the facilities are allocated to the right persons, NROCC commissioned a census of the old Causeway fishing village, which was completed in July last year.His Worship the Mayor of Portmore, Keith Hinds, commended the contractors “for really doing a splendid job”, noting that “this facility is a first-class fishing village”.Minister of Transport and Works, Hon. Michael Henry (right) engages in a light moment with Representative of the Causeway Fisher Folk Friendly Society, Marva Lynch, (left) during a ceremony held on Friday, October 30 to officially open the Portmore Fishing Village Complex in St. Catherine. Sharing in the moment is His Worship the Mayor of Portmore, Keith Hinds.“It is one that I hope to replicate in the future in other areas in the municipality…such as Hellshire Beach. I want to have (it) developed in a fashion such as this,” he stated.Mayor Hinds suggested that the municipality be allowed to develop a market adjacent to the new fishing village. “It will augur well for the business of the fisher folk. It would bring more people to your place of business,” he contended.The management and operation of the fishing village will be undertaken by a committee comprising representatives of the Portmore Municipality, the Fisheries Division of the Ministry of Agriculture and Fisheries, fishermen and fish vendors.Representative of the Causeway Fisher Folk Friendly Society, Marva Lynch, in expressing gratitude on behalf of the group, promised to maintain and take care of the facility.“We appeal to the surrounding communities and we ask for your co-operation and your support so that we may co-exist peacefully. We ask that you not only look at us as just mere fish vendors and fishermen, but as a body of people doing a meaningful job in this great country,” she stated.Fish vendor Maria Martin, who spoke to JIS News following the ceremony, said she was appreciative of the newly established fishing village. “We hope that the customers will come out now that we are around this area,” she said.Professing to be one of the oldest vendors on the Causeway, Hyacinth Brown told JIS News that she has been plying her trade at the site since 1980. She said she was glad to be moving to the new facility, as business has dwindled since they were removed from the Causeway some three years ago. RelatedPortmore Fishing Village Opens RelatedPortmore Fishing Village Opens Portmore Fishing Village Opens AgricultureOctober 31, 2009 RelatedPortmore Fishing Village Opens
Parts Of Sydney Red Zone Downgraded From Tonight VIC PremierMore Victorians will be able to return home safely from Sydney this week with updated health advice allowing some border restrictions to be downgraded.Premier Daniel Andrews and Chief Health Officer Brett Sutton announced today that, due to the reduced exposure risk and low community transmission in some areas of Greater Sydney, a number of red zone Local Government Areas (LGAs) will transition to orange – allowing Victorians in those areas to return home if they want to.As of 6:00pm (Victorian AEDT) Monday 18 January, the Blue Mountains, Wollongong and all Greater Sydney LGAs except for Blacktown City, Burwood, Canada Bay City, Canterbury-Bankstown, Cumberland, Fairfield City, Inner West, Liverpool City, Parramatta City and Strathfield Municipality will be declared an orange zone due to the improved epidemiological conditions there.Anyone who has been in the LGAs of Blacktown City, Burwood, Canada Bay City, Canterbury-Bankstown, Cumberland, Fairfield City, Inner West, Liverpool City, Parramatta City and Strathfield Municipality in the last 14 days (other than for transit), is still not permitted to travel to Victoria without an exemption, exception or essential worker permit.People from these 10 LGAs who have already applied for an exemption application will not need to reapply.The updated orange zone listing overrides the previous classification as a red zone and applies to the last 14 days. Anyone who is now in an orange zone and meets the permit criteria can now apply for an Orange Zone Permit from 6:00pm tonight.Travel from an orange zone requires people to self-isolate, get tested within 72 hours of arrival and remain in quarantine until they receive a negative result.Travellers must also confirm they have not been in any of the remaining 10 red zone LGAs in Greater Sydney within the past 14 days (other than for transit), have not been in close contact with a coronavirus case and do not have any coronavirus symptoms.In addition, New South Wales border towns with Victoria will move to a green zone from 6:00pm tonight, ensuring easier movement for people on either side of the border.This includes Albury City, Balranald Shire, Bega Valley Shire, Berrigan Shire, City of Broken Hill, Edward River Council, Federation Council, Greater Hume Shire, Hay Shire, Lockhart Shire, Murray River Council, Murrumbidgee Council, Snowy Monaro Regional Council, Snowy Valleys Council, City of Wagga Wagga and Wentworth Shire.Cross-border communities do not need to apply for a travel permit, as long as they carry a valid form of ID with their address – like a driver licence – and have not been in a current orange or red zone area in the last 14 days.Anyone living in a cross-border community who has been in an orange zone in the last 14 days (other than for transit) – such as the Greater Sydney area, must apply for an Orange Zone Permit and agree to the conditions including the requirement to get tested within 72 hours of arrival and remain in self-quarantine until they receive a negative result.Anyone living in a cross-border community who has been in one of the 10 LGAs currently in the red zone in the last 14 days cannot travel to Victoria without an exemption, exception or essential worker permit.Exemption applications will no longer be required for those LGAs being downgraded to an orange zone – unless people have also been in a red zone in the last 14 days – and will not be considered. People can apply for an Orange Zone Permit via the Service Victoria website at service.vic.gov.au.Victorians have been incredible in getting tested and the Government continues to urge everyone if you have any symptoms at all – please get tested and stay home until you get your result.As stated by Premier Daniel Andrews“We know this has been a difficult time for Victorians who have been staying in Sydney and want return home. We’ll continue to review remaining red zones every day and will downgrade them as soon as it’s safe to do so.” As stated by Victorian Chief Health Officer Brett Sutton“We’ve been examining the data from Sydney closely and I’m pleased to be able to downgrade a number of areas of Greater Sydney. I’m asking everyone returning from an orange zone to please get tested within that 72-hour timeframe after they arrive home, and isolate until they have their result.” /Public Release. 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Bowman walked away physically unharmed, but probably shaking in his boots a little.RELATED COMMENTSSHARE YOUR THOUGHTS Porsche Cayman liable to get a lighter, more powerful trim We encourage all readers to share their views on our articles using Facebook commenting Visit our FAQ page for more information. RELATED TAGSNon-LuxuryNew VehiclesNon-Luxury PlayThe Rolls-Royce Boat Tail may be the most expensive new car everPlay3 common new car problems (and how to prevent them) | Maintenance Advice | Driving.caPlayFinal 5 Minivan Contenders | Driving.caPlay2021 Volvo XC90 Recharge | Ministry of Interior Affairs | Driving.caPlayThe 2022 Ford F-150 Lightning is a new take on Canada’s fave truck | Driving.caPlayBuying a used Toyota Tundra? Check these 5 things first | Used Truck Advice | Driving.caPlayCanada’s most efficient trucks in 2021 | Driving.caPlay3 ways to make night driving safer and more comfortable | Advice | Driving.caPlayDriving into the Future: Sustainability and Innovation in tomorrow’s cars | Driving.ca virtual panelPlayThese spy shots get us an early glimpse of some future models | Driving.ca The Rolls-Royce Boat Tail may be the most expensive new car ever Trending Videos Chevrolet’s Camaro is likely getting the Silverado’s four-cylinder turbo See More Videos The most stressful part of a drag race shouldn’t come after the finish line, but it certainly did in this case when a parachute failed to hold up its end of the bargain for Pro Mod driver Mike Bowman.Having finished a 5.89-second quarter-mile pass going 410 kilometres per hour in a race at Gateway Motorsports Park, Bowman’s chute only partially deployed out the back of his vehicle and sent the driver down the remainder of the track with just a hope and a prayer.You can see the brakes doing their best to slow down the vehicle, but the saving grace comes in the extended dirt patch and additional netting at the end of the track.
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AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 06 NOV 2013 Related AppleiPad 3iPad Air Previous ArticleKazam unveils first smartphonesNext ArticleSmart glasses may save field services $1B by 2017 – Gartner Apple faces 5G modem wait KT makes LG Electronics trade-in move Ken has been part of the MWC Mobile World Daily editorial team for the last three years, and is now contributing regularly to Mobile World Live. He has been a telecoms journalist for over 15 years, which includes eight…More Read more Ken Wieland Tags Devices Google taps retail with NYC store Author HomeDevicesNews iPad Air cheaper to make than iPad 3 Apple’s lowest-end iPad Air model – 16GB of NAND flash memory and no cellular connection – is $42 cheaper to make than the entry-level iPad 3, according to preliminary results from a teardown by IHS.Bill of materials (BOM) and manufacturing costs for the older model cost $316, but come in at just $274 for the lowest-end iPad Air.Apple is managing to trim costs for higher-end Air versions too.The iPad Air with 16GB of NAND flash memory and cellular connectivity has a BOM of $304, a 6 per cent reduction from $325 for an equivalently-equipped 3G iPad (based on a final pricing estimate for the device at the time of the release in 2012).When the $6 manufacturing cost of the iPad Air is added in, the total cost to make the tablet increases to $310.“While the iPad Air slims down in size, the profit margins are getting fatter,” said Andrew Rassweiler, senior director, cost benchmarking services for IHS. “Although the Air’s new, ultrathin display and touch screen are more expensive than for the third-generation iPad, Apple has held the line on cost by taking advantage of price erosion in other areas.”The profitability of the iPad Air rises dramatically as the NAND memory capacity increases. For example, the 32GB model costs Apple only $8.40 more to produce but has a retail price that’s $100 higher.Moreover, the iPad Air leverages the same components and suppliers that are used in the iPhone 5s and 5c as much as possible. For example, the same Apple-designed Samsung-manufactured A7 processor found in the iPhone 5s – with some variations – are used.The Air also uses the same memory to support the A7 processor as the 5s, employing 1GB of low-power Double Data Rate 3 (LPDDR3) DRAM.And similar to the 5s for the core baseband and RF transceiver functions, the Air employs the same suite of chips: the MDM9615, WTR1605L and PM8018 from Qualcomm.Communication breakdownIn contrast to the processor and baseband segments, the RF/power amplifier (PA) modules in the iPad Air are different compared to the iPhone 5s, which, says IHS, makes a big difference to Apple.The RF/PA section in the iPad Air supports LTE bands for all US carriers with a single-model iPad (there are not different wireless versions for each US carrier). This isn’t the case for the iPhone 5s, says IHS, probably due to space constraints in the smaller smartphone form factor.Also, the RF/PA subsystem in the iPad Air is laid out on 40 per cent more surface area in the printed circuit board than the comparable function in the iPhone 5s.Apple has also reduced the capacity of the battery in the iPad Air compared to the previous iPad. Battery capacity in the iPad Air is 32.9 watt hours (Wh), down 23 per cent from 42.5Wh in the 3G model.IHS says this is most likely because of lower power consumption in the display backlight. The iPad Air uses only 36 light-emitting diodes (LED) to illuminate the liquid-crystal display (LCD), down from 84 in the earlier-generation Pad.Fewer LEDs results in lower electricity demand, allowing the cut in battery power.The newest iPad has major differences in the microphones as well. The Air uses digital microphone technology rather than the analog parts in the third-generation model.Beforehand, Apple has exclusively used analog microphones in all its smartphones and tablets — bar the iPad 2, which sported a digital micro-electromechanical system (MEMS) microphone from Analog Devices.In another major departure, Apple is employing two microphones in the Air, as opposed to one in the previous models. The second microphone likely performs noise cancellation, says IHS.Another difference is that iPad Air uses microphones from STMicroelectronics instead of parts from Knowles and AAC found in the other iPad models.
Loon pushes FCC for E-band access Alphabet deflates Loon Alphabet subsidiary Loon inked a deal with Uganda’s Civil Aviation Authority (UCAA) to begin flights over the country, allowing it to supply connectivity services in hard-to-reach areas and potential disaster zones.At a media event in capital city Kampala, UCAA director general David Kakuba signed the agreement with Loon head of government relations Anna Prouse.Following the announcement, newspaper Daily Monitor reported Loon would engage with telecommunications companies on the logistics of supplying connectivity to distant parts of the country and zones prone to natural disasters.The agreement follows a number of test flights of Loon’s high altitude ballons, which act as floating mobile towers, in Uganda and neighbouring countries.Loon service was deployed as a direct response to natural disasters in the Americas in 2017, following flooding in Peru and in hurricane-hit Puerto Rico.Last month Telefonica signed a deal with Loon to use its balloons to extend its reach in rural areas of Peru, with launch scheduled for early 2020. Subscribe to our daily newsletter Back Tags Home Loon cleared for take-off in Uganda Related LoonUganda Chris Donkin Previous ArticleOppo makes move beyond smartphonesNext ArticleXiaomi readies low cost 5G smartphone Author Alphabet deshincha los globos de Loon AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 10 DEC 2019 Chris joined the Mobile World Live team in November 2016 having previously worked at a number of UK media outlets including Trinity Mirror, The Press Association and UK telecoms publication Mobile News. After spending 10 years in journalism, he moved… Read more
HELENA – Police are trying to piece together what led a dog trainer to shoot and kill a state trooper along a roadside in southwestern Montana, prompting a manhunt that ended with the suspect found dead in his truck.That’s only the first of several unanswered questions surrounding the killing of Montana Highway Patrol officer David DeLaittre, 23, who was found dead of a gunshot wound in his vehicle on Wednesday afternoon.Police later found the shooter, Errol Brent Bouldin, 56, dead in his 1999 green Ford F250 pickup truck in Broadwater County south of Townsend, which is about 35 miles north of Three Forks.Still unknown is what led to the encounter between Bouldin and DeLaittre off Montana Highway 2 just outside of Three Forks, where the Gallatin, Jefferson and Madison rivers converge to form the Missouri River.Gallatin County Sheriff James Cashell said police also don’t know yet how Bouldin died, whether he took his own life and what weapon or weapons were used to kill DeLaittre and himself.Cashell said more information would be released at a 2 p.m. press conference on Thursday.Bouldin’s ex-wife, Debra Bouldin of Camp Verde, Ariz., told The Associated Press in a telephone interview that he was a dog trainer and that she had not spoken to him since he left Arizona in January 2006.The year before, he nearly died from a rattlesnake bite. Debra Bouldin said that experience left him a changed man.“You know how when people have trauma they either become so thankful about everything about life or else they become bitter against life? Brent went to the bitter side,” she said. “That was a very life-changing thing for him. What happened after that, I honestly can’t tell you.She said her prayers were with the trooper’s family.More than 100 federal, state and local law enforcement officers from across southwestern Montana responded to the shooting and authorities closed Highway 2 from the junction of U.S. Highway 287 to Interstate 90 at Three Forks, about 70 miles southeast of Helena.The Gallatin County Sheriff’s Office said Bouldin lived in Three Forks. Public records show he previously lived in Belgrade, a town about 20 miles away.Belgrade police Sgt. David Keen said a warrant for Bouldin’s arrest was issued on Dec. 3, 2009, on a contempt charge, meaning Bouldin either failed to appear in court or did not comply with a court order. Keen said he did not know why the contempt warrant was issued.DeLaittre was sworn in as a trooper in November 2008. He initially was stationed in Chinook and then transferred to Bozeman in April 2010, Department of Justice spokeswoman Judy Beck said.The Bozeman Daily Chronicle reported that DeLaittre was from Three Forks, where his parents and two sisters live.Seven other Montana Highway Patrol officers have died in the line of duty, two by shooting, according to the Association of Montana Troopers. Stay Connected with the Daily Roundup. Sign up for our newsletter and get the best of the Beacon delivered every day to your inbox. Email